It is not necessary to perform ribosomal RNA (rRNA) depletion for the Small RNA-Seq Library Prep, as the protocol has been designed for total RNA as input.
Additional magnetic bead-based size selection can also be used to remove longer library products after the library prep has been completed.
It is not recommended to use RiboCop for rRNA depletion if you intend to use the RNA for downstream Small RNA-Seq Library Prep. This is because the small RNA fraction can be reduced during the purification steps of the RiboCop protocol.
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