To achieve a higher nucleic acid concentration, the amount of FFPE Lysis Buffer can be reduced from 110 μL to a minimum of 70 μL. This is beneficial for samples with a small total surface area. However, the reduction my result in a When reducing the amount of lysis buffer, please scale down proportionally the volumes of the other reagents. Please keep in mind that scaling down may also result in more difficult handling and a lower yield, yields especially if the FFPE sample contains excess paraffin.
...