What is the typical RNA yield?

The average yield of RNA obtained will depend on the sample type being used, the amount of starting material, the species, growth conditions, and the developmental stage of the sample. For instance, a typical RNA extraction from mouse liver yields approximately 4.0 – 4.5 µg total RNA / mg tissue, of which 3.0 – 3.5 µg contribute to the large RNA fraction and 0.6 µg contribute to the small RNA fraction. The general yield of extracted RNA for mouse brain is 1 µg / mg tissue. For 1 x 10⁶ human cells, around 10 µg of RNA can be extracted.